On older AMD Radeon cards, some versions of AMD Catalyst Control Center (CCC) allow you to override application mipmap settings and choose between performance and quality. The higher you set the slider to "Performance," the blurrier the texture becomes. Conversely, moving the slider towards "Quality" sharpens your images and hud elements.
Some users who have older versions of CCC have reported that their blurry HUD elements issue were fixed by moving the slider more towards "Quality".
On AMD Radeon cards with the new versions of Radeon Settings, players have found that changing the setting called "Texture Filtering Quality" (where it used to be Mipmapping has helped resolve blurry HUD/Inventory/Main Menu issues. You can change between High, Standard, and Performance; and depending on your system, changing to one of these settings may help remove the blurriness in your game.
You can go into your AMD Radeon Settings, and disable all of AMD graphics optimization features for Don't Starve or Don't Starve Together to see if that makes a difference when your GPU tries to launch or render the game.
More information about the AMD Radeon Settings can be found here: https://www.amd.com/en/support/kb/faq/dh-012
If you find that your characters, environments, or game world are blurry, this may be because you have certain settings enabled in-game. Check our help article for more information on this.